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As far as I'm aware - the answer is no - because it wouldn't work like you'd expect.
Buttons created by an addon that cast spells or target enemies only work out of combat, so there wouldn't really be any point creating an addon like one you're describing.
The alternative might be to use a bar modification addon that places the normal toolbar in the middle of the screen, with the ability you want to use on it. But then you'd see that toolbar all the time. Not ideal.
Perhaps instead you could look into an addon that alerts you when an ability becomes available, and try to figure out how you can bind more abilities with the keys you have at your fingertips. Alt, shift, ctrl can all be used with other buttons to provide more keyboard combinations.
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